Solubility and dissolution performances of spray-dried solid dispersion of Efavirenz in Soluplus
نویسندگان
چکیده
منابع مشابه
Enhancement of Dissolution Rate of Efavirenz by Solid Dispersion Technique
Efavirenz is an HIV-1 specific, non-nucleoside reverse transcriptase inhibitor (NNRTI).It is an antiretroviral agent indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection, which is not soluble in water and lower absorption in gastric fluid. In order to improve the solubility and oral absorption of the drug in gastric fluid and to enhance its dissolution rate, soli...
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Formulation Development and Dissolution Rate Enhancement of Efavirenz by Solid Dispersion Systems
The aim of this study was to enhance the dissolution rate of efavirenz using solid dispersion systems (binary and ternary). A comparison between solvent and fusion method was also investigated. Solid dispersions of efavirenz were prepared using polyethylene glycol 8000, polyvinylpyrrolidone K30 alone and combination of both. Tween 80 was incorporated to obtain a ternary solid dispersion system....
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ژورنال
عنوان ژورنال: Drug Development and Industrial Pharmacy
سال: 2016
ISSN: 0363-9045,1520-5762
DOI: 10.1080/03639045.2016.1205598